ABSTRACT
Background: Prostatic carcinoma shows an unusually wide range of biological potential with well-known disparity between incidence and mortality for disease. Clinico-pathological studies suggests that angiogenesis and tumor neovascularity contributes to pathogenesis of prostate cancer. The aim of this study to present study was done to assess the validity of angiogenesis as a suitable prognostic marker in various prostatic disease specially the neoplasm’s including the malignant ones. Settings and design are Retrospective study.Methods: The present study of evaluation of angiogenesis as a prognostic marker in prostatic neoplasm especially carcinoma of prostate was done with 40 biopsy sample. The biopsy sample were obtained by suprapubic prostatectomy specimen and trans rectal needle biopsy specimen. Tissue sections were subjected to routine H and E staining. For demonstration of angiogenesis staining for reticulin fibers was applied.Results: The microvessels density increases as the severity of lesion increases from benign to pre-neoplastic to frankly malignant. The micro vessel density in malignant lesions is approximately thrice that in benign lesions. Conclusions: Very few studies have been done in prostatic lesions Hence an attempt is made to demonstrate and correlate angiogenesis as a tumour marker.
ABSTRACT
Introduction: Blood disorders are very common among different age groups. They usually range from anemias to advanced hematological malignancies. Material and Methods: The present observational study was conducted in the Department of Pathology, M.L.B. Medical College, Jhansi to find out the incidence of different hematological disorders. marrow examination was done. SPSS software was used for data analysis. Results: Hematological disorders were more common among males (63.55%) and among those aged Bone between 21-30 yrs (27.1%). Anemia was the most common diagnosis in 49 cases (41.52%) followed by leukemia in 16 cases (13.56%). Thirteen cases (11.02%) were diagnosed as malarial parasite positive in bone marrow examination. Conclusion: Bone marrow examination is a useful test in reaching the final diagnosis.